M. Audet, K.L. White, B. Breton, B. Zarzycka, G.W. Han, Y. Lu, C. Gati, A. Batyuk, P. Popov, J. Velasquez, D. Manahan, H. Hu, U. Weierstall, W. Liu, W. Shui, V., Katritch, V. Cherezov, M.A. Hanson, R.C. Stevens “Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor” Nat. Chem. Biol. 15, 11-17 (2019). doi: 10.1038/s41589-018-0160-y. PMC6289721. More »
L. Susac, M.T. Eddy, T. Didenko, R.C. Stevens, K. Wüthrich “A2A adenosine receptor functional states characterized by 19F-NMR” Proc. Natl. Acad. Sci. USA 115, 12733-12738 (2018). pii: 201813649. doi: 10.1073/pnas.1813649115. PMC6294957. More »
S. Yang, Y. Wu, T.H. Xu, P.W. de Waal, Y. He, M. Pu, Y. Chen, Z.J. DeBruine, B. Zhang, S.A. Zaidi, P. Popov, Y. Guo, G.W. Han, Y. Lu, K. Suino-Powell, S. Dong, K.G. Harikumar, L.J. Miller, V. Katritch, H.E. Xue, W. Shui, R.C. Stevens, K. Melcher, S. Zhao, F. Xu “Crystal structre of the Frizzled 4 receptor in a ligand-free state” Nature 560, 666-670 (2018). doi: 10.1038/s41586-018-0447-x. More »
P. Popov, Y. Peng, L. Shen, R.C. Stevens, V. Cherezov, Z.J. Liu, V. Katritch “Computational design of thermostabilizing point mutations for G protein-coupled receptors” Elife pii: e34729 (2018). doi: 10.7554/eLife.34729. PMC6013254. More »
M.T. Eddy, Z.G. Gao, P. Mannes, N. Patel, K.A. Jacobson, V. Katritch, R.C. Stevens, K. Wüthrich “Extrinsic tryptophans as NMR probes of allosteric coupling in membrane proteins: application to the A2A adenosine receptor” J. Am. Chem. Soc. 140, 8228-8235 (2018). doi: 10.1021/jacs.8b03805. PMC6192543. More »
C. Cao, Q. Tan, C. Xu, L. He, L. Yang, Y. Zhou, Y. Zhou, A. Qiao, M. Lu, C. Yi, G.W. Han, X. Wang, X. Li, H. Yang, Z. Rao, H. Jiang, Y. Zhao, J. Liu, R.C. Stevens, Q. Zhao, X.C. Zhang, B. Wu “Structural basis for signal recognition and transduction by platelet-activating-factor receptor” Nat. Struct. Mol. Biol. 25, 488-495 (2018). doi: 10.1038/s41594-018-0068-y. More »
X. Liu, Z.G. Gao, Y. Wu, R.C. Stevens, K.A. Jacobson, S. Zhao “Salvianolic acids from antithrombotic traditional Chinese medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors” Sci. Rep. 8, 8084 (2018). PMC5967328. More »
S. Qin, M. Meng, D. Yang, W. Bai, Y. Lu, Y. Peng, G. Song, Y. Wu, Q. Zhou, S. Zhao, X. Huang, J.D. McCorvy, X. Cai, A. Dai, B.L. Roth, M.A. Hanson, Z.J. Liu, M.W. Wang, R.C. Stevens, W. Shui “High throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening” Chem. Sci. 9, 3192-3199 (2018). PMC5916221. More »
Z. Yang, S. Han, M. Keller, A. Kaiser, B.J. Bender, M. Bosse, K. Burkert, L.M. Kogler, D. Wifling, G. Bernhardt, N. Plank, T. Littmann, P. Schmidt, C. Yi, B. Li, S. Ye, R. Zhang, B. Xu, D. Larahammar, R.C. Stevens, D. Huster, J. Meiler, Q. Zhao, A.G. Beck-Sickinger, A. Buschauer, B. Wu “Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor” Nature 556, 520-524 (2018). PMC5920736. More »
Y. Peng, S. Zhao, Y. Wu, H. Cao, Y. Xu, X. Liu, W. Shui, J. Chen, S. Zhao, L. Shen, J. Ma, R.J. Quinn, R.C. Stevens, G. Zhong, Z.J. Liu “Identification of natural products as novel ligands for the human 5-HT2C receptor” Biophys. Rep. 4, 50-61 (2018). PMC5860131. More »
M. Vass, A.J. Kooistra, D. Yang, R.C. Stevens, M.W. Wang, C. de Graaf “Chemical diversity in the G protein-coupled receptor superfamily” Trends Pharmacol. Sci. 39, 494-512 (2018). pii: S0165-6147(18)30035-X (2018). More »
J. Singla, K.M. McClary, K.L. White, F. Alber, A. Sali, R.C. Stevens “Opportunities and challenges in building a spatiotemporal multi-scale model of the human pancreatic β–cell” Cell 173, 11-19 (2018). PMC6014618. More »
