F. Zhao, C. Zhang, Q. Zhou, K. Hang, X. Zou, Y. Chen, F. Wu, Q. Rao, A. Dai, W. Yin, D.D. Shen, Y. Zhang, T. Xia, R.C. Stevens, H.E. Xu, D. Yang, L. Zhao, M.W. Wang “Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor. Elife 10, e68719 (2021). doi: 10.7554/eLife.68719. More »
Z. Wang, T. Gurlo, A.V. Matveyenko, D. Elashoff, P. Wang, M. Rosenberger, J.A. Junge, R.C. Stevens, K.L. White, S.E. Fraser, P.C. Butler “Live-cell imaging of glucose-induced metabolic coupling of β and α cell metabolism in health and type 2 diabetes” Commun. Biol. 4, 594 (2021). doi: 10.1038/s42003-021-02113-1. More »
J. Singla, K.L. White, R.C. Stevens, F. Abler “Assessment of scoring functions to rank the quality of 3D subtomogram clusters from cryo-electron tomography” J. Struct. Biol. Online 19 Mar (2021). doi: 10.1016/j.jsb.2021.107727. More »
C. Martin, L.E. Gimenez, S.Y. Williams, Y. Jing, Y. Wu, C. Hollanders, O. Van der Poorten, S. Gonzalez, K. Van Holsbeeck, S. Previti, A. Lamouroux, S. Zhao, D. Tourwe, R.C. Stevens, R.D. Cone, S. Ballet “Structure based design of melanocortin 4 receptor ligands based on the SHU-9119-hMC4R cocrystal structure. J. Med. Chem. 64, 357-369 (2021). doi: 10.1021/acs.jmedchem.0c01620. More »
J. Yu, L.E. Gimenez, C.C. Hernandez, Y. Wu, A.H. Wein, G.W. Han, K. McClary, S.R. Mittal, K. Burdsall, B. Stauch, L. Wu, S.N. Stevens, A. Peisley, S.Y. Williams, V. Chen, G.L. Millhauser, S. Zhao, R.D. Cone, R.C. Stevens “Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding” Science 368, 428-433 (2020). online 24 April 2020. doi: 10.1126/science.aaz8995. PMC7567314. More »
F. Wu, L. Yang, K. Hang, M. Laursen, L. Wu, G.W. Han, Q. Ren, N.K. Roed, G. Lin, M.A. Hanson, H. Jiang, M.W. Wang, S. Reedtz-Runge, G. Song, R.C. Stevens “Full-length human GLP-1 receptor structure without orthosteric ligands” Nat. Commun. 11, 1272 (2020). doi: 10.1038/s41467-020-14934-5. PMC7062719. More »
R. Lamichhane, J.J. Liu, K.L. White, V. Katritch, R.C. Stevens, K. Wüthrich, D.P. Millar “Biased signaling in the G-protein-coupled receptor β2AR is governed by conformational exchange kinetics” Structure 28, 371-377 (2020). doi: 10.1016/j.str.2020.01.001. PMC7213800. More »
M. Audet, K. Villers, J. Velasquez, M. Chu, C. Hanson, R.C. Stevens “Small-scale approach for precrystallization screening in GPCR X-ray crystallography” Nat. Protoc. 15, 144-160 (2020). doi: 10.1038/s41596-019-0259-y. More »
Q. Zhou, D. Yang, M. Wu, Y. Guo, W. Guo, L. Zhong, X. Cai, A. Dai, W. Jang, E.I. Shakhnovich, Z.J. Liu, R.C. Stevens, N.A. Lambert, M.M. Babu, M.W. Wang, S. Zhao “Common activation mechanism of class A GPCRs” eLife 8, e50279 (2019). doi: 10.7554/eLife.50279. More »
T. Claff, J. Yu, V. Blais, N. Patel, C. Martin, L. Wu, G.W. Han, B.J. Holleran, O. Van der Poorten, K.L. White, M.A. Hanson, P. Sarret, L. Gendron, V. Cherezov, V. Katritch, S. Ballet, Z.J. Liu, C.E. Müller, R.C. Stevens “Elucidating the active d-opioid receptor crystal structure with peptide and small-molecule agonists” Sci. Adv. 5, eaax9115 (2019). doi: 10.1126/sciadv.aax9115. PMC6881160. More »
X. Chen, Y. Xu, L. Qu, L. Wu, G.W. Han, Y. Guo, Y. Wu, Q. Zhou, Q. Sun, C. Chu, J. Yang, L. Yang, Q. Wang, S. Yuan, L. Wang, T. Hu, H. Tao, Y., Sun, Y. Song, L. Hu, Z.J. Liu, R.C. Stevens, S. Zhao, D. Wu, G. Zhong “Molecular mechanism for ligand recognition and subtype selectivity of α2C adrenergic receptor” Cell Rep. 29, 2936-2943.e4 (2019). doi: 10.1016/j.celrep.2019.10.112. More »
L. Qu, Q. Zhou, Y. Xu, Y. Guo, X. Chen, D. Yao, G.W. Han, Z.J. Liu, R.C. Stevens, G. Zhong, D. Wu, S. Zhao “Structural basis of the diversity of adrenergic receptors” Cell Rep. 29, 2929-2935.e4 (2019). doi: 10.1016/j.celrep.2019.10.088. More »
