Y. Zheng, L. Qin, N.V. Ortiz Zacarias, H. de Vries, G.W. Han, M. Gustavsson, M. Dabros, C. Zhao, R. Cherney, P. Carter, D. Stamos, R. Abagyan, V. Cherezov, R.C. Stevens, A.P. IJzerman, L.H. Heitman, A. Tebben, I. Kufareva, T.M. Handel “Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists” Nature 540, 458-461 (2016). PMC5159191. More »
M.T. Eddy, T. Didenko, R.C. Stevens, K. Wüthrich “2-Adrenergic receptor conformational response to fusion protein in the third intracellular loop” Structure 24, 1-8 (2016). PMC5144828. More »
T. Hua, K. Vemuri, M. Pu, L. Qu, G.W. Han, Y. Wu, S. Zhao, W. Shui, S. Li, A. Korde, R.B. Laprairie, E.L. Stahl, J.-H. Ho, N. Zvonok, H. Zhou, I. Kufareva, B. Wu, Q. Zhao, M.A. Hanson, L.M. Bohn, A. Makriyannis, R.C. Stevens, Z.-J. Liu “Crystal structure of the human cannabinoid receptor CB1” Cell 167, 750-762 (2016). PMC5322940. More »
A. Batyuk, L. Galli, A. Ishchenko, G.W. Han, C. Gati, P.A. Popov, M.Y. Lee, B. Stauch, T.A. White, A. Barty, A. Aquila, M.S. Hunter, M. Liang, S. Boutet, M. Pu, Z.J. Liu, G. Nelson, D. James, C. Li, Y. Zhao, J.C. Spence, W. Liu, P. Fromme, V. Katritch, U. Weierstall, R.C. Stevens, V. Cherezov “Native phasing of x-ray free-electron laser data for a G protein-coupled receptor” Sci. Adv. 2, e1600292 (2016). PMC5035125. More »
S. Yuan, H.C. Chan, H. Vogel, S. Filipek, R.C. Stevens, K. Palczewski “The molecular mechanisms of P2Y1 receptor activation” Angew. Chem. Int. Ed. Engl. 55, 10331-10335 (2016). PMC4996126. More »
X. Lv, J. Liu, Q. Shi, Q. Tan, D. Wu, J.J. Skinner, A.L. Walker, L. Zhao, X. Gu, N. Chen, L. Xue, P. Si, L. Zhang, Z. Wang, V. Katritch, Z.J. Liu, R.C. Stevens “In vitro expression and analysis of the 826 human G protein-coupled receptors” Protein Cell 7, 325-337 (2016). PMC4853319. More »
X.E. Zhou, X. Gao, A. Barty, Y. Kang, Y. He, W. Liu, A. Ishchenko, T.A. White, O. Yefanov, G.W. Han, Q. Xu, P.W. de Waal, K.M. Suino-Powell, S. Boutet, G.J. Williams, M. Wang, D. Li, M. Caffrey, H.N. Chapman, J.C. Spence, P. Fromme, U. Weierstall, R.C. Stevens, V. Cherezov, K. Melcher, H.E. Xu “X-ray laser diffraction structure determination of the rhodopsin-arrestin complex” Sci. Data 3, 160021 (2016). PMC4828943. More »
D. Yang, C. de Graaf, L. Yang, G. Song, A. Dai, X. Cai, Y. Feng, S. Reedtz-Runge, M.A. Hanson, H. Yang, H. Jiang, R.C. Stevens, M.W. Wang “Structural determinants of binding the seven-transmembrane domain of the glucagon-like peptide-1 receptor” J. Biol. Chem. 291, 12991-13004 (2016). PMC4933217. More »
L. Susac, C. O’Connor, R.C. Stevens, K. Wüthrich “In-membrane chemical modifications (IMCM) for site-specific chromophore labeling of GPCRs” Angew. Chem. Int. Ed. 54, 15246-9 (2015). PMC4747426. More »
R. Laminchhane, J.J. Liu, G. Pljevaljcic, K.L. White, E. van der Schans, V. Katritch, R.C. Stevens, K. Wüthrich, D.P. Millar “Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor 2AR” Proc. Natl. Acad. Sci. USA 17, 14254-14259 (2015). PMC4655547. More »
R.L. Miller, A.A. Thompson, C. Trapella, R. Guerrini, D. Malfacini, N. Patel, G.W. Han, V. Cherezov, G. Calo, V. Katritch, R.C. Stevens “The importance of ligand-receptor conformational pairs in stabilization: spotlight on the N/OFQ G protein-coupled receptor” Structure 23, 2291-9 (2015). PMC4670589. More »
H. Zhang, H. Unal, R. Desnoyer, G.W. Han, N. Patel, V. Katritch, S.S. Karnik, V. Cherezov, R.C. Stevens “Structural basis for ligand recognition and functional selectivity at angiotensin receptor” J. Biol. Chem. 290, 29127-39 (2015). PMC4705918. More »
